gccase | Glucocerebrosidase is imported into mitochondria and preserve

Keyword	CPC	PCC	Volume	Score	Length of keyword
gccase	0.61	1	7745	82	6

Keyword	CPC	PCC	Volume	Score
gccase	1.78	0.4	5066	85
gc cases	1.73	0.8	8476	38
gccases01/cca	0.08	1	5377	6
gccase login	0.26	0.2	8906	11
gccases03/taw	0.14	0.5	9718	17
gccases02/cca	0.82	0.2	3945	15
gccase pfl	1.46	0.3	236	43
gccase pspc	0.17	0.5	6248	20
gccase government of canada	0.29	0.9	2352	44
gccases01/taw	1.38	1	6626	94
gccases02/taw	0.54	0.4	2510	21
gccases02/cca/index.jsp	1.24	0.4	8331	65

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Glucocerebrosidase is imported into mitochondria and preserves …
nature.com

https://www.nature.com/articles/s41467-023-37454-4

WebApr 6, 2023 · Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher’s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD).

DA: 26 PA: 5 MOZ Rank: 46

Glucocerebrosidase mutations disrupt the lysosome and now the …
nature.com

https://www.nature.com/articles/s41467-023-42107-7

WebOct 11, 2023 · β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in ...

DA: 25 PA: 13 MOZ Rank: 85

Targeting neuronal lysosomal dysfunction caused by β ... - Nature
nature.com

https://www.nature.com/articles/s41467-023-37632-4

WebApr 12, 2023 · Mutations in glucocerebrosidase (GCase) cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Using a fusion protein comprising ...

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Government corporate support services at Public Services and
canada.ca

https://www.canada.ca/en/public-services-procurement/services/corporate-support.html

WebGCcase (accessible only on the Government of Canada network) The GCcase program is a common case management system solution for federal departments and agencies, which enables organizations to automate, manage, track and …

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Glucocerebrosidase: Functions in and Beyond the Lysosome
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141376/

WebMar 9, 2020 · Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose. Inherited deficiency of GCase causes the lysosomal storage disorder named Gaucher disease (GD). In GCase-deficient GD patients the accumulation of GlcCer in …

DA: 29 PA: 9 MOZ Rank: 9

Glucosylceramide accumulation in microglia triggers STING
science.org

https://www.science.org/doi/10.1126/scisignal.adk8249

WebMar 26, 2024 · Glucocerebrosidase (GCase), which is encoded by the GBA1 gene, is a lysosomal enzyme that hydrolyzes glucosylceramide (GC) into ceramide and glucose ().GCase deficiency caused by GBA1 mutations is associated with Gaucher disease (GD), the most prevalent lysosomal storage disorder (2, 3).Notably, in individuals with one …

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Glucocerebrosidase - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Glucocerebrosidase

WebGlucocerebrosidase. β-Glucocerebrosidase (also called acid β-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, or GCase) is an enzyme with glucosylceramidase activity ( EC 3.2.1.45) that cleaves by hydrolysis the β-glycosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism that is abundant in cell ...

DA: 13 PA: 7 MOZ Rank: 99

GC Enterprise Architecture/Enterprise Solutions - wiki - GCcollab
gccollab.ca

https://wiki.gccollab.ca/GC_Enterprise_Architecture/Enterprise_Solutions

WebGCcase Cloud Enterprise platform for Case Management, 2019-08-22; GCcase Service catalogue,2018-06-28; Shared Case Management Solution (SCMS), 2018-03-08; Contact Centre: SSC – Contact Center Modernization Update, 2021-04-08; Finance: TBS – TeamMate+ Enterprise Initiative, 2021-01-14; FMT Coordinated Model and GC Digital …

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Glucocerebrosidase and its relevance to Parkinson disease
biomedcentral.com

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-019-0336-2

WebAug 29, 2019 · Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related synucleinopathies. A great deal is known about GBA1, as mutations in GBA1 are causal for the rare autosomal storage disorder …

DA: 73 PA: 82 MOZ Rank: 81

GCase Enhancers: A Potential Therapeutic Option for Gaucher …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325019/

WebJul 2, 2022 · Gaucher disease (GD) is the most common LSD of glycosphingolipids and originates from mutations in the GBA gene (chromosome 1q21−22), which encodes for the lysosomal enzyme acid-β-glucosidase (glucocerebrosidase or GCase, EC 3.2.1.45, MIM*606463). GCase is the enzyme responsible for the hydrolysis of glucosylceramide …

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